SOD复合酶对肢体缺血再灌流损伤的保护作用（红细胞SOD活力与胞膜脂质过氧化的观察）

PROTECTIVE EFFECTS OF COMPOUND SOD ENZYME ON LIMB ISCHEMIA REPERFUSION INJURY(Studying on SOD activity of red cells and lipid peroxidation of cell membranes)

本文观察ＳＯＤ复合酶对肢体缺血再灌流损伤中，ＯＦＲ引发红细胞膜脂质过氧化及其胞内ＳＯＤ活力变化的保护作用，结果表明，模型组红细胞内ＳＯＤ活力显著降低（Ｐ＜０．０１），胞膜脂质过氧化反应增强，ＭＤＡ生成量明显增高（Ｐ＜０．０５）．揭示ＯＦＲ产生异常，红细胞抗氧化能力减弱，ＳＯＤ复合酶治疗组红细胞膜脂质过氧化作用受到明显抑制，胞内ＳＯＤ活力显著增高（Ｐ＜０．０１）．由此提示，在组织缺血再灌流损伤过程中，如适时补以外源性ＳＯＤ复合酶，将对ＯＦＲ介导的细胞膜损伤，具有一定的保护作用。

ln this paper,the protective effects of compound SOD enzyme against red cell mem-branes-lipid peroxidation and the change of intracellular SOD activity induced by oxygen free radi- cal in limb ischemia- reperfusion injury were studied. This experiment showed that in limb is- chemia- reperfusion injury group the activity of SOD in red cell decreased significantly(P<0.01),celluler membrane-lipid peroxidation was enhanced and malondialdehyde content of red cell mem- branes increesed(P<0. 05). In the group treated with compound SOD enzyme,lipid peroxidation of red cell membranes was inhibited and the activity of SOD in red cells augmented markedly(P< 0.01).The results demonstrated that compound SOD enzyme could be used to protect against oxygen free radicals nediated cell membranes damage in the process of tissue ischemia-reperfu- slon lnjury.