摘要
根据羟基哌喹和汉防己甲素治疗矽肺的不同作用机理,将其配成复方治疗Wistar大鼠实验性矽肺,以复方组与单用组比较:复方甲组动物肺中胶原蛋白的含量少(P<0.05),肺大体标本融合病灶的范围小,矽结节病理分级轻1级,在统计学上有显著意义,X线胸片以小阴影为主,病变较轻。实验证明复方羟基哌喹对大鼠实验性矽肺的治疗有增效作用。
The composite was made according to the different mechanism for treating silicosis with Qianghansu (Plydroxypiperaquine and Tetrandrine).It was used for treating the experimental silicosis of Wistar rat.In comparison with the single drug group, the content of collagen in the lung of the rat in the composite group was less (P<C0.05) and the range of the confluent foci in the gross lung was also less.The pathological classification for the silicotic nodules was 1 grade less.On the chest radiograph there were mostly small opacities.There was a significant difference between the composite group and the single drug group.These results suggest that the composite Qianghansu had the synergism action for treating the experimental silicosis of the rat.
出处
《第二军医大学学报》
CAS
CSCD
北大核心
1989年第1期1-7,共7页
Academic Journal of Second Military Medical University
关键词
复方羟汉素
矽肺
大鼠
composite Qianghansu
experimental silicosisj therapeutic effect
rats
