原发性高血压病患者血浆神经肽Y浓度的改变及其性别差异

CHANGES OF PLASMA NEUROPEPTIDE Y CONCENTRATIONS AND THEIR SEXUAL DIFFERENCES IN PATIENTS WITH SPONTANEOUS HYPERTENSION

用放射免疫分析方法测定原发性高血压病患者与健康志愿者在平板运动试验前后的血浆神经肽Ｙ（ＮＰＹ）浓度。结果显示，男性患者运动前显著高于对照组（１４５±６与１２８±５ｐｇ／ｍｌ，ｐ＜０．０５），运动后无显著改变；女性患者在运动前与对照组无显著差别（１２４±６与１３２±７ｐｇ／ｍｌ），运动后与男、女对照组均升高。

lasma neuropeptide Y (NPY)concentrations before and after graded running exercise test were measured by radio-immunoassay in patients with spontaneous hypertension and in healthy volunteers.The results showed that in male patients,the NPY concentration before exercise was higher than the control(145±6 vs 128±5pg/ml,p< 0.05).And there was no significant change in NPY concentration after exercise. But in female patients,the NPY concerntration before exercise was not significantly different from the control(124±6 vs 132±7pg/ml)and after exersise it was elevated significantly as the male and the female control volunteers.