卵巢恶性肿瘤的雌孕激素受体研究

THE STUDY OF ESTROGEN AND PROGESTERONE RECEPTORS IN OVARIAN CANCER

用葡聚糖－活性碳吸附法（ＤＣＣ法）对８７例卵巢恶性肿瘤的雌激素受体（ＥＲ）及孕激素受体（ＰＲ）进行了测定。ＥＲ、ＰＲ的阳性率分别为５０．６％和５８．６％。在不同组织类型中，宫内膜样癌的ＥＲ与ＰＲ高于其它癌。ＰＲ与临床分期呈负相关。多因素分析显示ＥＲ、ＰＲ均阳性者预后好。ＥＲ与ＰＲ的测定有助于了解病人预后，对卵巢癌的内分泌治疗有一定指导作用。

evels of estrogen receptor(ER) and progesterone receptor(PR)in ovarian cancer tissues were examined withregard to their clinical significance. Hormone receptor content was determined with the DCC method, receptor val-ues higher than 10 fmol/mg protein were considered positive. Of 87 samples from patients with ovarian concer,50.6%were ER-positive, 58.6%PR-positive; 34. 5%were ER-positive,PR-positive(ER+PR+ ),and 25.3%ER-negative, PR-negative(ER-pR-).There was a positive correlation between ER and PR,P<0. 01. The PRlevel in stage I ovarian cancer was higher than in advanced diseases(FIGO stage Ⅲ and Ⅳ ),P<0 05,and the ERand pR level in endometrioid histology was higher than those in the other histologic types,P<0.05.There was nocorrelation between receptor status and patient’s age,menopausal status or tumor grade of epithelial ovarian can-cer. A Cox proportional hazards regression model identified hormone receptor status as an independent prognosticfactor for survival,both ER and PR positive tumors had a better prognosis,P<0.01.We suggest that ER and PRbe useful in predicting the prognosis of patients with ovarian cancer, and we expect that the determination of ERand PR will play a role in the hormonal therapy of ovarian cancer.