乳腺癌ER、PR状态与生物学特性的研究

STUDY OF ER AND PR LABELING AND BIOLOGICAL FEATURES OF BREAST CARCINOMA

应用ＰＡＰ免疫组化染色法对９６例有随访资料的乳腺癌行ＥＲ、ＰＲ检测．结果发现ＥＲ在导管内癌、导管浸润癌、炎性癌阳性率较高；粘液癌、髓样癌中等；单纯癌最低。ＰＲ在导管内癌、导管浸润癌、髓样癌较高；粘液癌、炎性癌中等；单纯癌最低。ＥＲ、ＰＲ与组织学分级、淋巴结转移及肿块大小呈负相关，而与５年生存率呈正相关。患者年龄与ＥＲ差异无显著意义；ＰＲ有显著意义（Ｐ＜０．０５）．表明ＥＲ、ＰＲ状态对乳腺癌的生物学行为有一定预测意义。

ER and PR in 96 cases of breast carcinoma followed up were studied with PAP immunohis to chemical method.The results showed the ER-Postive rates of intraduct.inrasive duct and inflammatory carcinoma were higher.mucious and medullary carcinoma were middle simple carcinoma was the lowest ;PR-Postive rates of intraduct.inrasive duct and medullary carcinoma were higher.mucious and inflammatory carcinoma were middle.simple carcinoma was the lowest.ER and PR showed negative relation with histologic grade .lymph node metastasis and tumor size and positive relation with 5-year surriral rate. There was no statistically significance between patients and ER.but a significance between the age and PR. Our results indicated that ER and PR labelings have prognostic value for the biologic features of breast carcinoma.