摘要
EB病毒诱导永生化人上皮细胞发生恶性转化李宝民,纪志武,刘振声,曾毅(中国预防医学科学院病毒学研究所,北京100052)关键词EB病毒,促癌物,上皮细胞转化EB病毒与鼻咽癌有着密切关系 ̄[1,2],已经证明EB病毒潜伏膜蛋白(LMPl)能引起大鼠细胞...
e established CR2-positive 293 cells, then, used EB virus to infect these cellsdirectly,In these cells EB virus can replicate and express EB viral antigens.EBvirus-infected epithelial cells grow in piles with multiple cellular layers and loss of contactinhibition. In soft agar culture,EB virus-infected cells together with TPA (12-0-tetardecanoyl-phorbol-13- acetate)treatment formed more and larger clones.When these cells were transplanted subcutaneously into nude mice,and treated with TPA,poorly differentiatedcarcinomas were induced.
出处
《病毒学报》
CAS
CSCD
北大核心
1995年第4期371-373,共3页
Chinese Journal of Virology
关键词
EB病毒
促癌物
上皮细胞
转化
EB virus,Tumor promoters ,Transformation of epithelial cells