摘要
本文报告大叶延胡索对实验性心肌缺血和对冠状动脉血流量的作用。结果表明大叶延胡索能提高常压下小鼠对缺氧的耐受能力,延长大剂量异丙肾上腺素所致的高耗氧状态下的存活时间;减轻大剂量异丙肾上腺素所致的心肌缺血性坏死的程度;缩小大鼠左冠状动脉结扎后12h的心肌梗塞范围。增加猫冠状动脉血流量,轻度降低血压,减慢心率。
In this paper, the effects of rhizoma corydalis turtschaninovii f.yanhusuo (large leaf type5 LLYH) on experimental myocardial ischemia and coronary blood flow are reported.LLYH was showed to be active in increasing the tolerance of mice to monobaric hypoxia and prolonging survival time of the animal under the high oxygen consumption condition induced by large dose of isoproterenol.It decreased the severity of myocardial ischemic necrosis induced by large dose of isoproterenol in mice and reduced the extent of myocardial infarction in Wistar rats 12 h after ligation of the root of th,e left coronary artery.In anesthetized open chest cats, coronary blood flow was increased by LLYH infusion with slight decrease in heart rate and blood pressure.
出处
《第二军医大学学报》
CAS
CSCD
北大核心
1989年第2期119-122,共4页
Academic Journal of Second Military Medical University
关键词
延胡索
心肌缺血
疾病模型
动物
rhizoma corydalis turtschaninovii f.yanhusuo (large leaf type)
coronary blood flow
myocardial ischemic necrosis
myocardial infarction
disease models,animal
