药物性急性胃粘膜病变89例分析

Analysis of 89 Cases of Acute Gastric Mucosal Lesions Induced by Drugs

经纤维内窥镜检查确诊急性胃粘膜病变(AGML)344例,其中药物诱因者89例(25.9％).常见的药物依次为:阿斯匹林类22例(24.7％),消炎痛19例(21.3％),固醇类激素18例(20.2％),保泰松10例(11.2％),利血平9例(10.1％),其它药物11例(10.4％).内窥镜所见出血糜烂性胃炎59例(66.3％),急性溃疡19例(21.3％),疮痘样糜烂11例(12.4％).疮痘样糜烂主要分布于粘膜皱襞,且病变多发,常无出血表现.

344 cases with acute gastric mucosal lesions diagnosed by fiberscopy were studied. Among them 89 cases (25.9%) were induced by drugs. The common drugs as the cause of illness were as follows: 22 cases (24.7%) were aspirin; 19 cases (21 .3% ), indomethacine; 18 cases (20.2%), steroid hormones; 10 cases (11 .2 % ), phenylbutazone; and 9 cases (10. 1% ), reserpine .The manifestions of the fiberscopy examination of these lesions were: 59 cases (66.3%) of hemorrhagic erosion gastritis, 19 cases(21 .3%) of acute gastric ulcer and 11 cases (12. 4%) of smallpox erosion. The latter were mainly distributed mucosal wrinkle and the lesions were multiple and usually without helilorrhage.