心肺手术后血清CK及CK-MB的改变

CHANGES IN SERUM CK AND MB ISOENZYME AFTER CARDIO-PULMONARY OPERATION

系列测定34例心肺手术病人血清CK及MB同功酶活力。34例病人分3组:(1)闭式二尖瓣分离术组;(2)体外循环术组;(3)肺手术组。病人中无一发生急性心肌梗塞。术后3组病人血清CK及MB同功酶活力均较术前为高(P<0.01)。肺手术组术后血清CK活力较闭式二尖瓣分离术组高(P<0.05)。血清MB同功酶活力术前、术后3组之间比较则无统计学差异(P>0.05)。结果表明:心肺手术可致:血清CK及MB同功酶升高,心肌缺血性损害的程度难以由血清CK-MB活力来评定。

Serial determinations of serum CK and MB isoenzyme activities were made in 34 patients after cardiopulmonary operation.They were divided into three groups : (1) closed mitral commissurotomy, (2) cardiopulmonary bypass, and (3) pulmonary operation.Acute myocardial infarction (AMI) did not occur in all the patients.Postoerative serum CK and MB iso;nzyme activities wer; all increased (P<0.01).Postoperative serum CK was higher in the pulmonary operation group than that in the closed mitral commissurotomy group (P<0.05).There was no significant difference of serum MB isoenzyme among the three groups before and after operation.The results show that cardiopulmonary operation may induce serum CK and MB isoenzyme rising.The degree of myocardial ischemia damage cannot be confirmed by serum CK-MB activities.