TPN病人血清钾、钠、钙、镁、铁、铜、锌、锰的含量变化

CHANGES OF Na, K, Ca, Mg, Fe, Cu, Zn AND Mn LEVELS IN SERA OF TPN PATIENTS

对TPN治疗5d以上的30例患者血清和TPN病人常用的16种药液中8种金属元素(K,Na,Ca,Mg,Fe,Cu,Zn,Mn)的含量进行了测定。TPN药液中常量元素含量较高,微量元素含量甚微。在TPN60d和171d先后观察到2例严重锌缺乏症患者,其血清锌浓度分别降低至 5.O0μmol/L和1.22μmol/L,并有明显的锌缺乏症状和体征。我们的结果表明:短期TPN病人至少在2周内一般不会发生金属元素缺乏症,但长期TPN病人则可能发生某些金属元素的缺乏,特别是锌缺乏症。

In this study, we determined the levels of 8 minerals (Na, K, Ca, Mg, Fe, Cu, Zn and Mn)in sera of 30 patients receiving total parenteral nutrition (TPN) for more than 5 d and tested the 8 mineral concentrations in the 16 drugs and solutions often usrd for TPN.The concentrations of Na, K, Ca, and Mg in the TPN drugs and solutions were much higher than those of the trace elements (Fe, Cu, Zn and Mn).Severe zinc deficiency was found in 2 patients receiving TPN for about 60 d and 171 d and their s:rum zinc concentrations lowered to 5.00 umol/L and 1.22 umol/L, respectively with clinical symptoms and signs induced by zinc deficiency.Our results show that mineral deficiencies do not occur at least within 2 weeks in short-term TPN patients, but in long-term TPN patients mineral deficiencies, especially zinc deficiency may appear.