犬肠缺血性休克血浆β内啡肽样免疫活性物质含量变化及其与血流动力学的关系

DYNAMIIC CHANGES OF PLASMA BETA-ENDORPHIN-LIKE-IMMUNOREACTIVITY AND THESR CORRELATION WITH HEMO-DYNAMICS DURING INTESTINAL ISCHEMIA SHOCK IN DOGS

以狗肠缺血性休克模型,动态观察了血浆β内啡肽泽免疫活性物质(ir-β-PP)含量变化及其与血流动力学的关系。实验表明,肠缺血性休克时血浆ir-β-EP含量明显升高,且与MAP、CO、SV、CI等血流动力学指标变化呈明显负相关。认为β内啡肽(β-EP)参与肠缺血性休克发生发展的病理过程。本实验为研究肠缺血性休克的发生机理提供了新的依据。

Five mongrel dogs were used to investigate the dynamic changes of beta-cndo-rphin-Uke-immunoriactivity(ir-β-EP)and thdr correlation with hemodynamics during intestinal ischemia shock.It was shown that plasma levels of ir-β-EP were increased significantly during shock and were significantly correlated with the decrease in MAP, CO, SV,and CI.Our results give the direct evidence that endogenous opiate beta-endorphin is involved in the cardiovascular pathophysiology of intestinal ischemia shock.