AFP和HBsAg、IgG及Alb在人体肝癌和癌周肝组织中的双重免疫定位

DOUBLE IMMUNOLOCALIZATION OF AFP, HBsAg, IgG AND ALBUMIN IN HUMAN LIVER CANCER AND ITS SURROUNDING LIVER TISSUE

为了探讨人体肝(广品山)宿主肝细胞AFP的来源和性质,应用双重免疫酶组化技术(PAP法)进行了AFP与HBsAg、IgG及Alb的检测和定位。结果证实确有一部分宿主肝细胞可以自己合成AFP。并通过对其慢性肝病背景和肝不典型增生的形态学分析,认为是一类具有癌前期生物学活性的细胞。它的复现是与其遭受HBV的感染所致的肝损伤有一定关联。

In order to investigate the origin and nature of AFp in the host liver cells, the authors used a double immunoenzymatic technique (PAP method) to detect and localize AFP, HBsAg, IgG and albumin.The results demonstrated that the AFP might be synthesized by the partial host liver cells.The morphologic analysis of the background of chronic liver disease and the frequence of liver cell dysplasia for the same tissue section strongly suggested that they were a kind of cells which had the preneoplastic biologic activity and the resurrection of AFP in the host hepatocytes were related to injury induced by HBV infection.