摘要
通过对家兔视网膜铁离子与脂质过氧化反应的关系及药物对其作用的研究,探讨视网膜铁锈症的治疗方法。用家免视网膜S_9片段进行体外试验,发现二价铁与三价铁均可明显诱发此反应,乙二胺四乙酸及维生素E对此诱发反应抑制较强,超氧化物岐化酶对其抑制稍弱,而还原型谷胱甘肽则促进该反应。
The relationship between iron ions and lipid peroxidation and their inhibition with drugs on rabbits' retina were investigated, in order to explain the mechanism of sideresis bulbi and search for its treatment. In rabbit-retina S9 fraction in vitro, it was found that both ferrous and ferric ion could induce lipid peroxidation markedly. Edetate (EDTA) and Vit.E inhibited iron-induced lipid peroxidation obviously, superoxide dismutase inhibited moderately, while reduced GSH promoted this reaction.
出处
《眼外伤职业眼病杂志》
北大核心
1989年第4期199-202,共4页
Journal of Injuries and Occupational Diseases of the Eye with Ophthalmic Surgeries
