富铬酵母抗动脉粥样硬化的研究

ANTI-ATHEROSCLEROSTIC EFFECTS OF CHROMIUM-ENRCHED YEAST IN KATS

本文观察了富铬酵母对早期动脉粥样硬化大鼠的预防及治疗作用。病理结果表明：在大鼠高脂饲料中按重量比加入０．１％的甲基硫氧嘧啶，在透射电镜下，大鼠主动脉内皮细胞可见大量空泡，内皮下可见典型的泡沫细胞，而给予富铬酵母（每０．４５ｇ／ＫｇＢｗ）预防组内皮细胞空泡较少；模型鼠改食普通饲料４０天，内皮下仍可见不典型泡沫细胞，内有空泡，而改食基础饲料并给富铬酵母治疗（０．２５ｇ／ＫｇＢｗ／ｄ），内皮下可见泡沫细胞，但空泡消失。在扫描电镜下，模型鼠主动脉内皮细胞肿胀、萎缩、排列紊乱，出现斑块状病变；给予富铬酵母预防组，内皮细胞排列正常，未见斑块病变；改食基础饲料用富铬酵母治疗组，内皮细胞形态与排列皆恢复正常。表明富铬酵母对大鼠早期动脉粥样硬化有明显预防及治疗作用。

The prophylatic and therapeutic effects of Chromium-enriched yeast(CEY)on early atherosclerosis were observed in rats.In order to obtain high-fat modelTianjin Medical Universityrats,these rats were fed on a high-fat diet for 80 days which methylthiouracil was addedto in a weight ratio of 1 :1000 during initial 20 days of the feeding.Nine high-fat modelrats fed on the high-fat diet and with Chromium-enriched yeast(0.45g/kg/d)served asthe CEY-prevented group.The CEY-treated group consisted of 9 high-fat model rats,which were fed on a nomal diet instead of the high-fat diet and were treated withChromium-enriched yeast (0.25g/kg/d)for 40 days.Pathological study showed that(1)under transmission electron-microscope, a large number of vacuoles were seen in theaortic endothelial cells from the high-fat model rats and typical foamy cells under theendothelium, while in the CEY-prevented group the vacuole was small in number; afterthe model rats were fed on a normal diet for 40 days ,nontypical foamy cells and thevacuoles still existed, while in the aortic endothelium form the model rats of the CEY-treated group the nontypical foamy cells were still seen but the vacules disappeared;and(2 ) under scanning electron microscope ,cellular swelling atrophy ,disorderlyarrangement and plaques formation were seen in the aortic endothelial cells from themodel rats but in the CEY-prevented group the plaques formation was not found andcellular arrangement were in order; In the CEY-treated group the arrangement andappearance of the endothelial cells were restored to normal.These results suggest thatthe Chromium-enriched yeast possesses obvious prophylatic and therapeutic effects onearly atherosclerosis in tats.