一种新的修复周围神经损伤的移植体—动物实验研究

A NEW IMPLANT FOR PERIPHERAL NERVE REPAR AN ANIMAL EXPERIMENTAL STUDY

在３０只大鼠实验中，用基膜或坐骨神经段桥接６０根坐骨神经的缺损。术后１５、３０、６０天，先后检测腓肠肌、比目鱼肌肌肉收缩力，再生轴索通过率、直径，并应用电子显微镜观察神经再生超微结构。术后６０天，基膜桥接组和神经桥接组均有良好功能恢复，两组间的各项数据差异均不显著。作者认为，基膜是一种良好的移植体，应能应用于修复周围神经损伤。

The Basal lamina /sciatic nerve segments were used as grafts tobridge the gaps between severed ends of 60 sciatic nerves in 30 Wistar rats.Nerveaxons regeneration in these grafts were assessed 15,30 and 60 days after operationwith the following observation items as criteria,i.e.contractian force of thegastrocnemius and soleus muscles as well as the diameter,rate of crossing over andultrastructure of regenerating axons.Two months after operation both the sciatic nervegraft group and the basal lamina graft group all gained satisfactory functional recovery;the differences in criteria data between the two groups were statistically insignificant.Inthe authors' opinion,the basal lamina ought to be good grafts for peripheral nerverepair.