糖尿病患者血清过氧化脂质测定的意义

DETERMINATION OF SERUM LIPID PEROXIDE IN DIBETIC PATIENTS

对已确诊的住院糖尿病患者共５０例进行血清过氧化脂质（ＬＰＯ）的测定，其水平明显高于正常对照组（Ｐ＜０．０１）。同时，测定了空腹血糖、糖基化血红蛋白，并按病程、病情轻重及有无血管并发症进行分组比较。结果：有血管并发症组ＬＰＯ增高与无血管并发症组有非常显著差异（Ｐ＜０．０１），病程＞１０年与病程（５年组有非常显著差异（Ｐ＜０．０１），糖基化血红蛋白＞１０％组与糖基化血红蛋白（１０％组有非常显著差异，空腹血糖不同各组间无显著差异（Ｐ＞０．０５）。说明ＬＰＯ增高与糖尿病血管并发症有一定关系，也与病程长短、糖基化血红蛋白多少有关。

The serum lipid peroxide(LPO )level ,blood glycose ,glycosylatedhemoglobin were determined in 50 cases of diabetic patients and in 24 blood donorsserving as controls. The results were as follows :(1)the LPO levels in diabetic patientswere higher than those in normal controls ( P<0. 01 ),(2) the LPO levels in diabeticpatients with blood vessel complications were obviously higher than those in patientswithout blood vessel complications (P<0.01),(3)there was significant difference inLPO level between the course over ten years and less five years ,and between theglycosylated haemoglobin content over 10 percent and less 10 percent( P<0. 01 ) and(4 ) the LPO levels had no marked difference among the groups whose fasting bloodglycose was different in concentrations(P>0.05).These results mean that theincrease in LPO level has relation with blood vessel complications, the course andglycosylated haemoglobin conte.