血清Ⅲ型前胶原（PCⅢ）在肝纤维化诊断中的意义

Significance of serum procollagen type Ⅲ(PCⅢ) in diagnosis of hepatic fibrosis

近年肝纤维化的血清学诊断已开始应用于临床。我们用放免法测定了正常人及急慢性肝病病人血清ＰＣⅢ含量共１２０例（急性肝炎２５例，慢迁肝１７例，慢活肝２０例，肝硬化２６例，肝癌８例，正常对照２４例），结果：肝硬化病人血清ＰＣⅢ含量明显增高，为正常对照组的３倍（２６３．７±３９．８４μｇ／Ｌ与９１．４４±１６．５２μｇ／Ｌ），慢活肝及肝癌亦明显增高。含量分布图显示此三组病例与正常对照组及慢迁肝组均无重叠，以肝硬化组更为明显。而且血清ＰＣⅢ与转氨酶、白蛋白、及胆红素等指标不相关。结果表明血清ＰＣⅢ测定可作为诊断肝纤维化的一个重要指标。

The diagnostic serology of hepatic fibrosis has been applied.In this study,the levels of serum PC Ⅲ(Precollagen TypeⅢ) were measured using radioimunoassay in 96 patients with acute or chronic liver diseases(25 acute hepatitis,20 CAH,17 CPH,26 HCH,anb 8 HCC) and 24 healthy persons.The levels of PCⅢ were abnormally increased in the patients with HCH (263.70±37.84μg/L),and three times as high as those of normal control group(91.44±16.52μg/L).The levels of PCⅢ in patients with CAH and HCC were also increased.Content distributive figure shows that these three groups didn't overlap with control or CPH, and the increase of serum PCⅢ levels wasn't correlative with serum ALT levels,albumin,and bilirubin. The results indicated that the determination of the serum PCⅢ levels may be useful in diagnosis of hepatic fibrosis.