维生素E、C和B_2协同抗大鼠体外、小鼠体内脂质过氧化及血脂的研究

The combined effects of vitamin E, C and B_2 on lipid peroxidation,blood lipids in rats and mice

为观察维生素Ｅ、Ｃ和Ｂ２联合应用的协同抗氧化作用，本研究采用Ｆｅ＋＋－半胱氨酸（ＣＹＳ）活性氧体系刺激大鼠肝匀浆ＬＰＯ形成及四氧嘧啶诱发小鼠高ＬＰＯ、高脂血症模型，结果显示，维生素Ｅ、Ｃ和Ｂ２三者联用的抗氧化作用最强，其次为其中两两组合或单一使用一种维生素；同时还表明，三种维生素联用可降低血中ＴＣ及ＴＧ含量，其效果优于两种维生素组合或单用维生素Ｅ。本研究为联用抗氧化维生素，使其发挥协同作用，从而在较低剂量情况下产生较高的抗氧化、调血脂效能提供了科学依据。

The combined effects of vitamin h, C and B2 on lipid peroxidation were investigated in Fe-Cys-induced liver homogenate on rats. Blood MDA of rats supplemented with vitamin E.C and B2 was significantly lower than those of rats supplemented with vitamin E and C,E and B2, C and B2.In alloxan-induced mice,the complex of three vitamin could markedly low blood TC and TG.