思密达局部止血作用的实验观察

Experimental investigation of the effect of Smecta on local hemostasis

采用人工急性损伤大鼠及蟾蜍肠系膜微血管后，喷滴思密达观察其局部止血作用。结果表明：使动物受损伤部出凝血时间缩短与对照组比较差异显著（Ｐ＜０．０１）；其微血管口径收缩量与对照组比较差异非常显著（Ｐ＜０．００１）；并使该部位微血管内血流速度减慢与对照组相比，差异明显（Ｐ＜０．０１）；电镜及光镜观察喷药的局部附着无定形的药物与ＲＢＣ、血小板混合型凝血块。

In this study we investigated the local hemostasis effect of Smecta which was sprayed on artifical vasculr injury in mesenteric blood vessels of rats and toads.The results showed that the bleeding and coagulation times of Smecta-treated animals were significantly shortened than control arimals which did not receive this treatment(P<0.01).The degree of vascular constricton in Smecta-treated animals differented sharply from control's (P<0.001).The lower blood flow velocity was seen in Smectatreated blood vessels (P<0.01).By electronic and light microscope, we found that the druhs sprayed on vessels formed a unregulate coagulate plug with RBC and platelets in site.