摘要
Ｃａ２＋与肿瘤代谢有着极为密切的关系。本文报道了钙拮抗剂异搏停作用于Ｈｃａ－Ｆ２５／ＣＬ－１６Ａ３细胞后胞内某些钙稳态指标的改变。结果表明，用药后细胞有分化现象且生长速度减慢，同时胞液Ｃａ２＋浓度和微粒体Ｃａ２＋－ＡＴＰ酶活性明显降低，而线粒体和微粒体贮钙水平显著升高，细胞核钙和细胞总钙明显下降。结果提示，钙拮抗剂可使肿瘤细胞内的钙分布发生变化，从而改变了与肿瘤细胞的分化和增殖密切相关的钙恒稳状态。
In this paper, some indexes of intracellular calcium homeostsis in the ascites hepatoma cell clones of 615 inbreeding strain mice, Hca-F25/CL-16A3 before and after treated with verapamil were determined. The result showed that after treated with 100μmol/L verapamil, the tatol calcium, the level of nucleus calcium, the cytosolic free Ca2+ concentration and the activity of microsomal Ca2+-ATPase obviously decreased,while the level of mitochondrial calcium and microsomal calcium in 16A3significantly increased. These results indicated that the Ca2+ antagonits could change the intracellular calcium homeostasis whose association with tumors has been confirmed by many papers.
出处
《大连医科大学学报》
CAS
1995年第3期172-174,共3页
Journal of Dalian Medical University
关键词
钙稳态
肿瘤转移
异搏停
肝癌腹水瘤
Calcium homeostasis
tumor metastasis
verapamil
Ca￣(2+)-ATPase
ascites hepatoma
