早期胃癌、癌旁病变的粘液组化及超微结构的观察——对胃癌组织发生的探讨

Histochemical and ultrastructural study of early gastric carcinoma and peri-cancerous lesions——An investigation of histogensin of early gastrtic carcinoma

本文报告了22例早期胃癌和癌旁病变,共有癌灶28个(3例多灶性癌)的粘液组化和超微结构观察。本组合并慢性萎缩性胃炎(85.93％)、肠化(81.22％)和中度及重度不典型增生(78.59％)。这些高发病变与早期胃癌发生有密切关系。从AB-PAS和HID染色结果,肠型癌灶20个(71.42％)、胃型癌灶5个(17.85％)和混合型癌灶3个(10.71％),结果表明人肠化在胃癌发生有重要意义。电镜观察肠型癌含有与癌旁肠化杯状细胞的粘液颗粒及微绒毛,显示肠化与胃癌发生密切相关。重度不典型增生上皮有类似癌细胞超微结构改变,提示不典型增生细胞是癌前病变。

The ultrastructural and mucinhistochcmical study of 28 cancerous lesions is reported.They respectively associated with atrophic gastritis in 85.93%,intestinal metaplasia in 81.82%,and dysplasia in 78.59%.So high incidence suggests a close relationship between the lesions and the development of early gastric carcinoma,By means of AB-PAS and HID staining the cancerous lesions of intestinal type 20(71.42%),gaslric type 5(17.85%) and mixed type 3(10.71%) show that intestinal metaplasia of colonic type seems closely relate to carcinoma.Studying the specimens from 6 gastric carcinomas of different histological type and pcricanccrous lesions by electron microscopy,there arc microvilli of different sizes and densities on their free surfaces in the cancer cells with granule formation.Some of the signet ring carcinoma cells contain goblet type mucous granules.The ultrastructuc of severe dysplasia closely resembles,gastric cancer cells.