严重烫伤早期外源性β-羟丁酸钠、胰岛素对大鼠骨骼肌蛋白质代谢的影响

Effects of Exogenous No-DL-3-Hydroxybutyrate and Insulin on Skeletal Muscle Protein Metabolism in Rats after Early Severe Burn Injury

本文就外源性β-羟丁酸钠(β-HOBNa)、胰岛素(Ⅰ)对37％体表严重烫伤大鼠骨骼肌蛋白质代谢的影响进行了研究。结果为伤后第4天血清乙酰乙酸(AcAc)无明显变化,游离脂肪酸(FFA)下降,尿3-甲基组氨酸(3-MH)和伤肢比目鱼肌蛋白质分解率明显增加。伤后连续三天注入β-HOBNa可降低尿3-MH和比目鱼肌蛋白质的分解率,但对其合成无明显影响。联合注入β-HOBNa和Ⅰ未见二者有明显的协同抗蛋白质分解的效应。

The effects of exogenous Na-DL-3-hydroxybutyate (3-HOBNa)and insulin(I) on skeletal muscle protein metabolism in rats inflicctcd with 37% TBSA full thickness scalding were studied It was found that the scrum acctoacctatc (AcAc) of the burned animals showed no significant difference from the control on the 4th day postburn,but the free fatty acid (FFA) decreased markedly and the urinary 3 - methylhistididne(3-MH) excretion and the protein de -gradation rate of the soleus muscle of the injured hind limb increased na kedly.Infusion of 3-HOBNa for 3 consecutive days following burns could lower the urinary 3-MH excretion and the protein,degradation rate of the soleus muscle with no significant influence on the skeletal muscle protein anabolism.Moreover,investigations revealed that there was no syncrgistic effect of insulin-kctone body combinalioan on the anti-catabolic capacity in burned rats.