弓形虫致神经系统感染的调查

An Investigation on Toxoplasma Infection to Nervous System

１９８７～１９９３年，以间接血凝试验（ＩＨＡ）随机调查了门诊和住院的神经系统疾病患者６７４例和非神经系统疾病患者２６０例的弓形虫感染情况。从上述９３４例患者中采集血清标本９３４份、脑脊液标本４０５份。查出血清抗体阳性者４７例（既往感染２６例、新近感染１７例、活动性感染４例），感染率为５．Ｏ３％，与国内人群平均感染率相符。脑脊液检查结果均为阴性。维吾尔族的感染率高于汉族，可能与生活习惯的差异有关。神经系统疾病患者的弓形虫感染率为６．３７％（４３／６７４），高于普通人群感染率，显著高于非神经系统患者的感染率１．５３％（４／２６０）。这一结果提示，在神经系统寄生虫性传染病的诊断中决不可忽视对弓形虫感染的检查。在４７例血清抗体阳性患者中，确诊为中枢神经弓形虫病者６例，在检测人数中的患者发现率为６４．２３／万，在血清阳性人数中的患者发现率为１２７６．５９／万，均显著高于国内５个省市自治区的调查结果。

An investigation on Toxoplasma infection with IHA was carried out to 674 patients suffered from nervous system diseases and 260 patients nonervous system diseases during 1987─1993. 934 sera and 405 CSF were collected and tested from aforesaid patients. 47 positive sera were detected and the Toxoplasma infection rate was 5. 03,which neared to that of the multitude in China. The Toxoplasma infection rate of patients suffered from NS diseases ( 6. 37%)was significantly higher than that of others( 1. 53%)(P< 0. 025). This result showed that the examination of Toxoplasma infection is necessary in diagnosis of parasitic diseases of nervous system. Of 47 patients with positive sera ,6 cases of Toxoplasmosis of central nervous sys-tem were diagnosed. The found rates of Toxoplasmosis patients in tested persons and in cases with positive sera were 64. 23/10 000 and 1276. 59/10000 respectively.Both the rates were significantly higher than the re-sults of similar studies in China.