LHRH类似物的设计和合成

DESIGN AND SYNTHESIS OF LHRH ANALOGS

为了寻找新的高效LHRH类似物,设计并合成了带有(D-Trp^6、desGly^(10))-LHRHEA,(D-Arg^6,desGly^(10))-LHRHEA变换5位残基的六个类似物。并应用体外黄体细胞培养法测定了它们的生理活性。

In the hope to find new superagonists of LHRH, here we report the synthesis of six analogs by changing residue 5 of [D-Trp^6 (or D-Arg^6), desGly^(10)]-LHRH-EA. For the convenience of comparison, the known compound [ D-Trp^6, desGIy^(10)]-LHRH-EA was also synthesized.These peptides were synthesized by Merrifield's solid phase method.The agonistic activities of these analogs are also reported.