摘要
独活为伞形科重齿毛当归(Angelica pubescens Maxim.F.biserrataShan et Yuan)的根及根茎,为常用中药,有祛风通络,活血舒筋,宜通百脉的作用。治腰膝酸痛,手脚挛痛。本研究证明独活有抑制血小板聚集抗血栓形成的作用,可能为独活善行血分,活血舒筋,宜通百脉的作用机制之一。我们将湖北资丘产独活以CH_2Cl_2,C_2H_5OH及H_2O提取。
Eight coumarins isolated from the alcohol extract of the Chinese drug'Duhuo' , the root of Angelica pubescents Maxim. f. biserrata Shan et Yuan (Umbelliferae) were elucidated to be columbianetin (Ⅰ), columbianetin acetate (Ⅱ), columbiadin (Ⅲ), osthol (Ⅳ), isoimperatorin (Ⅴ), bergapten (Ⅵ), xanthotoxin (Ⅶ), and columbianetin-β-D-glucopyranoside (Ⅷ), by chemical and spectral analysis, compound Ⅷ was isolated from plant for the first time.
All these coumarins were tested on platelet aggregation induced by 2μm ADP. Ⅰ, Ⅱ, Ⅲ, Ⅳ and Ⅷ showed strong inhibiting activity against platelet aggregation.
出处
《药学学报》
CAS
CSCD
北大核心
1989年第7期546-551,共6页
Acta Pharmaceutica Sinica
基金
国家科委自然科学基金
关键词
独活
香豆素
化学成分
甙
Angelica pubrscents Maxim. f. biserrata Shan et Yuan
Platelet aggregation
Columbianetin-β-D-glucopyranoside.