锕系核素促排药物——多元酚氨羧酸衍生物的合成

SYNTHESIS OF POLYPHENOLIC AMINOCARBOXYLIC ACID DERIVATIVES AS RADIO-ACTINIDES MOBILIZATION AGENTS

放射性元素的应用日益广泛。因放射性污染而造成的放射性核素进入体内并长期存在,是致癌的一个重要因素。使用螯合剂DTPA加速排出体内的放射性元素是临床上常用方法之一。但长期使用DTPA会造成体内所必需的二价金属离子的衰竭而影响人体正常代谢。同时DTPA对234钍的促排效果也不理想。一类新的邻苯二酚类螯合剂LICAM系列用于促排放射性核素钚,动物实验效果较好,但未见促排234钍的报道。

A series of polyphenolic aminocarboxylic acid derivatives were designed and synthesized for removal of incorporated radio-actinides. Thier chemical structures were confirmed by means of ~1HNMR and elemental analyses. Results of preliminary animal experiments showed that most of these compounds were effective for removal of ^(234)Thorium.