摘要
本文应用P-矩阵分光光度法同时测定十组分的复方降压片中维生素B_1、维生素B_6、利眠宁、盐酸异丙嗪、硫酸双肼肽嗪及氢氯噻嗪等六种组分的含量,并应用“条件数”原理来选择最佳测定波长,同时就实验误差,测定点数、“条件数”、组分浓度对处方量的偏差等因素对该法计算结果的影响进行了较为深入的探讨。被测组分的平均回收率均在97～10?%范围之内,变异系数(CV%)均小于或等于9.5(n=11)。
P-matrix method has been developed for the simultaneous determination of vitamin B_1, vitamin B_6, chlordiazepoxide, dihydralazins sulfate, promethazine hydrochloride and hydrochlorothiazide contained in compound reserpine tablets consisting of 10 components.The optimal wavelength for measurement was successfully selected based on the principle of condition number. The influence of experimental error, number of wavelength and condition number deviation of component concentration from formula were discussed. The average recoveries varied from 97～103% with CV≤9.5% (n=11).
出处
《药学学报》
CAS
CSCD
北大核心
1989年第11期853-858,共6页
Acta Pharmaceutica Sinica
基金
国家自然科学基金
关键词
分光光度法
复方降压片
组分含量
Vitamin B_1
Vitamin B_6
Chlordiazepoxide
Promethazine hydrochloride
Dihydralazine sulfate
Hydrochlorothiazide
P-Matrix spectrophotometry
