乳腺腺病和乳腺癌血型Y抗原的表达及其意义

The Significance of Expression of Y Blood Group Antigen in Breast Adenosis and Carcinoma

Lewis Y血型抗原(简称Y抗原)是一种胚胎性肿瘤相关抗原。对108例女性乳腺疾病标本检测结果显示:在正常乳腺组织和乳腺腺病Ⅰ级上皮增生者均无Y抗原表达;Ⅱ级上皮增生、Ⅲ级上皮增生,乳脲腺病癌变和乳腺癌中阳性率分别为22.8％、43.8％、60％和78.8％。在不同组织学类型的乳腺癌中Y抗原表达有差异,相同类型的癌组织中其表达亦呈明显不一致性。作为一种较特异的肿瘤标记物,Y抗原在乳腺癌的诊断和对肿瘤生物学行为的研究方面具有一定意义。乳腺腺病部分不典型增生病变中Y抗原表达的变化可能有助于判断其恶变倾向,帮助早期发现癌变病例。

The expression of Y antigen (EYA) of epithelial cells from 52 breast carcinomas (BC) , 5 malignant transformation of adenosis(MTA),46 adenosis and 5 normal breasts are assessed with ABC immunoperoxidase histocytochemical assay and Y hapten specific monoclonal antibody. The results show, no expression of Y antigen in both normal breast and epithelial hyperplastic grade (EHG) I of adenosis of breast. The positive ratio of EYA in EHG II, III, MTA and carcinoma of breast are 22.8%, 43.8%, 60%and78.8% respectively.The EYA is different from various histologic types of breast carcinomas and shows unequal distribution in the same type of cancer. Y antigen, as a specific tumor-associated marker, may be used in diagnosis of breast cancer and in promotion of the study in biologic behaviour of cancer. The EYA detection in epithelial atypic hyperplasia of adenosis of breast is useful to determine the tendency towards malignant transformation and a help to find out breast cancer in the early stage.