摘要
健康志愿者10例和老年消化性溃疡患者6例单剂量口服40mg法莫替丁(Fam)后,体内处置符合一室开放模型,老年患者T1/2为0.59±1.81h,药-时曲线下面积866.5±194ng·ml-1·h-1,肾清除率和总清除率分别为329±45.5ml/min和438±34ml/min,24hFam原型经肾排出量为总剂量的21.5%,与健康志愿者相比,消除明显减慢,血药浓度水平升高,临床使用时需调整剂量,避免由于药物在体内蓄积而引起的不良反应。
The pharmacokinetics of famotidine (Fam) were studied after the administration of a single oral dose of 40 mg to ten young healthy volunteers and six elderly patients with peptic ulcer. In elderly patients, the plasma elimination half-life was 6.59±1.81h. The area under plasma concentration-time curve was 866.5±194 ng. mg-1. h-1. Mean renal and total body clearance were 329±45.5 ml/min and 438±34 ml/min. About 21. 5% of the dose were recovered as unchanged Fam in urine within 24 h. Significant differences were oberved in most pharmacokinetic parameters between healthy volunteers and elderly patients. Thus reduction in drug dosage should therefore be necessary in elderly patients.
出处
《第二军医大学学报》
CAS
CSCD
北大核心
1995年第1期48-50,共3页
Academic Journal of Second Military Medical University
关键词
法莫替丁
药物动力学
老年人
famotidine
HPLC
pharmacokinetics
elderly patients