胃癌患者外周血单个核细胞白细胞介素2的诱生能力

The production of interieukin- 2 of peripheral blood mononuclear cells in pa tients with gastric cancer

应用［３Ｈ］－ＴｄＲ掺入法，测定３０例胃癌患者外周血单个核细胞白细胞介素２（ＩＬ－２）诱生能力。结果表明，胃癌患者ＩＬ－２诱生能力显著低于正常对照（Ｐ＜０．０１）及胃慢性良性病者（Ｐ＜０．０１）；随肿瘤进展，ＩＬ－２诱生能力逐渐降低（Ｐ＜０．０１）；肿瘤分化越差，ＩＬ－２诱生能力则越低（Ｐ＜０．０１）；血清可溶性ＩＬ－２受体（ｓＩＬ－２Ｒ）与ＩＬ－２诱生能力呈负相关（γ＝－０．７６３１，Ｐ＜０．０１）；去除肿瘤负荷，可降低血清ｓＩＬ－２Ｒ和升高ＩＬ－２诱生水平。

The production of interleukin-2 (IL-2) of poripheral blood mononuclear cells (PBMNCs) in 30 patients with gastric cancer was measured using [3H]-TdR incorporation method. The results showed that the production of IL-2 of PBMNCs in patients with gastric cancer was much lower than that of healthy subjects (P＜0. 01 ） and that of benign gastric disorders (P＜0. 01 ). The preduction of IL-2 of PBMNCs was lowered with the progression of the cancer (P＜0. 01 ); the poorly the cancer differentiated, the lower the production of IL-2 of PBMNCs (P＜0. 01 );serum soluble interleukin-2 receptor(sIL-2R) had negative correlation with the production of IL-2 of PBMNCs, and the latter was elevated and the level of serum sIL-2R was lowered when the cancer was resected.