冠状动脉的形态学和生物力学特性研究

Studies on morphology and biomechanics of the coronary arteries

深入了解冠状动脉的形态学和生物力学特性，不但有其生理学意义，而且对冠心病的防治研究也十分重要。１５年来，我们观察了家兔、猫和大鼠等常用实验动物冠状动脉的分支分布、分布类型、动静脉关系和心壁内动脉的分布规律等解剖学特征；研究了大鼠急性心肌梗塞时，心壁内血管的演变规律和侧支循环的建立过程。应用Ｓｔｒａｈｌｅｒ血管分支模型和Ｍｕｒｒａｙ最小能量原理，探讨了人和犬冠状动脉的几何形态学和最优化问题。对人和犬冠状动脉及与冠状动脉旁路移植术有关的胸廓内动脉和大隐静脉等血管的显微结构成分和生物力学特性进行了研究。

Morphology and biomechanics of the coronary arteries have been studied in the human and experimental animals since 1979. The types of the coronary distribution, the artery-vein relationship, and the intramural vascular patterns in the rabbit, cat, and rat, as well as the intramural vascular changes and the coronary collateral circulation in the healing process after the experimental myocardial infarction in the rat were investigated. Strahler model and Murray minimum energy principle were applied to the research of morphometry and optimal problems in the coronary trees of the human and canine. The microstructrual components and biomechanical properties of the coronary arteries and relative vessels were also analyzed in the human and canine.