摘要
为了探讨组胺H1受体(H1R)在哮喘发病中的作用,我们研究了特非那定对豚鼠离体气管螺旋条的作用。24只豚鼠随机分成2组,对其中一组予卵蛋白致敏。取其气管制成螺旋条,以组织浸浴法研究特非那定的作用。结果显示,1×10-6和1×10-7mol/L特非那定可抑制组胺诱发的气管螺旋条收缩、但不能使已收缩的螺旋条舒张,特非那定对组胺诱发致敏螺旋条收缩的抑制作用弱于非致敏螺旋条,提示致敏组织的H1R功能亢进或H2R功能低下,特非那定可用于哮喘预防性治疗。
To investigate the effect of histamine H_1 receptor(H_1R) on pathogenesis in asthma,we studied the effect of terfenadine on guinea-pig spirals in vitro.Twenty-four guinea-pigs were divided into two groups,one of them was sensitized with ovalbumine.The responses of the spirals to histamine and terfenadine were studied with tissue bath experiment.The results showed that(1)the dose-response curves of the spirals to hsitamine were shift to right in adding terfenadine prior to histamine and terfenadine had not any relaxation effect on contracted spirals;(2) the inhibition of terfenadine was weaker in the sensitized group than that in the normal group, suggesting that the reactivity of H_1R might be higher or H_2R lower in sensitized animals.Terfenadine might be used for prophylaxis of asthma.
出处
《第二军医大学学报》
CSCD
北大核心
1995年第5期451-453,共3页
Academic Journal of Second Military Medical University
基金
国家自然科学基金
关键词
特非那定
组胺H1
哮喘
气管螺旋条
terfenadine
receptor histamine
H_1
asthma
tracheal spiral
guinea pigs