AgNOR对星形胶质细胞瘤分级及预后判断的价值

AgNOR prognostic value in astrocytoma

为评价核仁组成区嗜银蛋白（ＡｓＮＯＲ）对判断神经胶质瘤分级及预后的价值，我们计数了４８例神经胶质肩的ＡｇＮＯＲ，并将肿瘤的大小与ＡｓＮＯＲ的数目进行相关性检验。结果发现：Ⅰ级、Ⅱ级和Ⅲ～Ⅳ级组的ＡｇＮｏＲ平均数目分别为２．２７±０．７３，３．９３±２．００及５．４２±１．５２；且Ⅰ级、Ⅱ级组均与Ⅲ～Ⅳ级组有显著差别（Ｐ＜０．０１）。３组肿瘤的最大直径分别为４．１、５．０６、６．１ｃｍ，所有肿瘤的最大直径与ＡｓＮＯＲ计数显著正相关（ｒ＝０．３７２４，ｐ＜０．０５）。推测：作为表示细胞增殖的ＡｇＮＯＲ计数除了在组织学分级上提供辅助的信息之外，在肿瘤预后判断中具有一定的价值。

in order to evaluate the prognostic value of the Argyrophilic NOR-associated proteins(AgNOR)in astrocytoma,AgNORs in 48 astrocytomas were measured.The correlation between AgNOR counts and major diameter of tumor was studied.The results showed that there was a trend that AgNOR counts in creased with the histologic grade,and that there was a significant difference between gradeⅠ,grade Ⅱand gradeⅢ～Ⅳ(P<O.01).It was also found that there was a positive correlation between AgNOR counts and major diameter of tumor.The rank correlation was 0.3724 and the corresponding P value was<O.05.We speculate that the increased AgNOR counts,which was considered as an indicator of cellular proliferation,could have a prognostic value besides its assistance in histological classification of astrocytoma.