摘要
采用随机对照的方法研究了中药(胃病冲剂)和小剂量三联疗法对慢性胃炎(CG)、消化性溃疡(PU)的疗效及幽门螺杆菌(Hp)清除和根除率,并进行了6~18月随访的远期疗效观察,206例CG,98例DU及91例GU,均随机分为胃病冲剂、三联疗法及对照组;疗程四周。81例PU获6~18月随访结果Hp根除率:胃病冲剂组53.85%,三联组69.83%,显著高于对照组(P<0.01)。DU及GU愈合率:胃病冲剂组79.31%、68.18%;三联组88.89%、81.81%;对照组72.08%、65.30%。胃病冲剂及三联疗法根除Hp后溃疡复发率:6个月后根除者12.50%,未根除者50.00%;12月后根除者10.53%;12月后根除者10.53%,未根除者为55.00%(P<0.01);18月后根除者1/8例,未根除者5/12例。冲剂组未发现副作用,三联组副作用少且轻微(8.96%)。本组资料表明:胃病冲剂和三联疗法均为安全、有效的抗Hp治疗方法。
The therapeutic effects of a mixture of Chinese traditional herb medicines(Berberinum,Rheum etc.)and triple therapy(CBS tetracycline and furanzolidone in small dosage(on 206 cases of chronic gastritis,98 cases of duodenal ulcer and 91 cases of gastric ulcer were compared and their effects to clear up Helicobactor pylori in these cases were also observed.A course of treatment consisted of 4 weeks.81 cases of peptic ulcer were followed up for 6 to 18 months,It was found that the clearance rate of H pylori was 53.85%in Chinese Herb Medicine(CHM)group,69.83%in triple therapy(TT)group and 0%in the control.The healing rate was 79.31%for duodenal ulcer(DU)and 68.18%for gastric ulcer(GU)in CHM group,88.89%(DU)and 81.81%(GU)in TT group and 73.03%(DU)and 65.30%(GU)in the control.In the group with the clearance of H.pylori,the relapse rate of peptic ulcer was 12.50%,10.53%and 12.5% in the 6th,12th and 18th month of follow up.While that in the group without H pylori clearance was 50.00%,55.00%and 41.67%in the 6th,12th and 18th month of followup.No obvious side effects were observed in CHM group and a few and mild side effects in TT group.Our findings indicate that both the treatments with Chinese herb medicines and a combination of 3 western drugs are safe and efficient for gastritis and peptic ulcer.
出处
《第三军医大学学报》
CAS
CSCD
北大核心
1995年第5期373-377,共5页
Journal of Third Military Medical University
基金
全军"八五"攻关项目