幽门螺杆菌相关性胃炎及消化性溃疡治疗研究

Study of the treatments for Helicobactor pulori-associated gastrictis and peptic ulcer

采用随机对照的方法研究了中药（胃病冲剂）和小剂量三联疗法对慢性胃炎（ＣＧ）、消化性溃疡（ＰＵ）的疗效及幽门螺杆菌（Ｈｐ）清除和根除率，并进行了６～１８月随访的远期疗效观察，２０６例ＣＧ，９８例ＤＵ及９１例ＧＵ，均随机分为胃病冲剂、三联疗法及对照组；疗程四周。８１例ＰＵ获６～１８月随访结果Ｈｐ根除率：胃病冲剂组５３．８５％，三联组６９．８３％，显著高于对照组（Ｐ＜０．０１）。ＤＵ及ＧＵ愈合率：胃病冲剂组７９．３１％、６８．１８％；三联组８８．８９％、８１．８１％；对照组７２．０８％、６５．３０％。胃病冲剂及三联疗法根除Ｈｐ后溃疡复发率：６个月后根除者１２．５０％，未根除者５０．００％；１２月后根除者１０．５３％；１２月后根除者１０．５３％，未根除者为５５．００％（Ｐ＜０．０１）；１８月后根除者１／８例，未根除者５／１２例。冲剂组未发现副作用，三联组副作用少且轻微（８．９６％）。本组资料表明：胃病冲剂和三联疗法均为安全、有效的抗Ｈｐ治疗方法。

The therapeutic effects of a mixture of Chinese traditional herb medicines(Berberinum,Rheum etc.)and triple therapy(CBS tetracycline and furanzolidone in small dosage(on 206 cases of chronic gastritis,98 cases of duodenal ulcer and 91 cases of gastric ulcer were compared and their effects to clear up Helicobactor pylori in these cases were also observed.A course of treatment consisted of 4 weeks.81 cases of peptic ulcer were followed up for 6 to 18 months,It was found that the clearance rate of H pylori was 53.85%in Chinese Herb Medicine(CHM)group,69.83%in triple therapy(TT)group and 0%in the control.The healing rate was 79.31%for duodenal ulcer(DU)and 68.18%for gastric ulcer(GU)in CHM group,88.89%(DU)and 81.81%(GU)in TT group and 73.03%(DU)and 65.30%(GU)in the control.In the group with the clearance of H.pylori,the relapse rate of peptic ulcer was 12.50%,10.53%and 12.5% in the 6th,12th and 18th month of follow up.While that in the group without H pylori clearance was 50.00%,55.00%and 41.67%in the 6th,12th and 18th month of followup.No obvious side effects were observed in CHM group and a few and mild side effects in TT group.Our findings indicate that both the treatments with Chinese herb medicines and a combination of 3 western drugs are safe and efficient for gastritis and peptic ulcer.