摘要
观察了链脲佐菌素(STZ)致糖尿病大鼠饮用钒酸钠4周前后的血糖、血脂、胰岛素及骨骼肌细胞膜胰岛素受体和葡萄糖摄取的变化。结果表明:钒酸钠在不通过刺激胰岛素分泌的情况下能纠正糖尿病大鼠的糖脂代谢紊乱,并能显著改善骨骼肌葡萄糖摄取的障碍,但对其细胞膜受体数目及亲和力影响不明显。提示钒酸钠的类胰岛素样作用可能与受体后效应──外周组织葡萄糖摄取利用增加有关。
In order to investigate the mechanism of deglucemic effects of sodium vanadate,the seurm level of glucose,lipid and insulin,the changes of insulin receptors on the cell membrane of skeletal muscles and the uptake of 2-deoxyglucose in the cells of skeletal muscles were observed in streptozotocin-induced diabetic rats before and 4 weeks after the administration of sodium vanadate,It was found that sodium vanadate significantly ameliorated the metabolic disorder of glucose and lipid without increasing insulin secretion and markedly improved glucose uptake of skeletal muscles without changing significantly the number and affinity of insulin receptors,These findings suggest that the insulin-like effects of sodium vanadate are related to the response in postreceptor level,that is,the increase of glucose uptake and utilization in peripheral tissues.
出处
《第三军医大学学报》
CAS
CSCD
北大核心
1995年第6期499-502,共4页
Journal of Third Military Medical University
关键词
糖尿病
钒酸钠
胰岛素受体
脱氧葡萄糖
diabetes mellitus
sodium orthovanadate
insulin receptor
2-deoxyglucose