钒酸钠降糖作用与胰岛素受体、葡萄糖摄取的研究

Study of deglucemic effects of sodium vanadate,insulin receptors and glucose uptake in diabetic rats

观察了链脲佐菌素（ＳＴＺ）致糖尿病大鼠饮用钒酸钠４周前后的血糖、血脂、胰岛素及骨骼肌细胞膜胰岛素受体和葡萄糖摄取的变化。结果表明：钒酸钠在不通过刺激胰岛素分泌的情况下能纠正糖尿病大鼠的糖脂代谢紊乱，并能显著改善骨骼肌葡萄糖摄取的障碍，但对其细胞膜受体数目及亲和力影响不明显。提示钒酸钠的类胰岛素样作用可能与受体后效应──外周组织葡萄糖摄取利用增加有关。

In order to investigate the mechanism of deglucemic effects of sodium vanadate,the seurm level of glucose,lipid and insulin,the changes of insulin receptors on the cell membrane of skeletal muscles and the uptake of 2-deoxyglucose in the cells of skeletal muscles were observed in streptozotocin-induced diabetic rats before and 4 weeks after the administration of sodium vanadate,It was found that sodium vanadate significantly ameliorated the metabolic disorder of glucose and lipid without increasing insulin secretion and markedly improved glucose uptake of skeletal muscles without changing significantly the number and affinity of insulin receptors,These findings suggest that the insulin-like effects of sodium vanadate are related to the response in postreceptor level,that is,the increase of glucose uptake and utilization in peripheral tissues.