摘要
目的:进一步探讨肾综合征出血热(HFRS)病毒对肾小球系膜细胞(MsC)的作用及其在HFRS肾脏损害发病机理中的作用,方法:用透射电镜观察HFRS病毒SR-11株感染的人MsC。结果:发现感染细胞多有不同程度的病理改变,胞浆内可见病毒样颗粒及病毒包涵体。结论:HFRS病毒对人MsC的直接损害作用可能与HFRS的肾脏损害有关。
Objective: To study the propagation and replication of HFRS
virus in human mesangial cells(MsC)and the relation of the effects of HFRS virus on MsC and
renal damage of HFRS.Methods :The SR-11 strair of HFRS virus infected human MsC was
observed by transmission electron microscope. Results :Varying cytopathies in subcellular
level of the infected MsC were found.Virion-like grannules and viral inclu-sion bodies were
detected in the cytoplasm, Conclusions :These results indicated that HFRS virus could
infectMsC,inducing metabolic disorders and functional disturbances as well as morphological
damages of the MsC,and suggested that renal damage of HFRS may be associated with direct
cellular injuries by HFRS virus.
出处
《第四军医大学学报》
1995年第1期21-24,共4页
Journal of the Fourth Military Medical University