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犬心肌急性缺血再灌注过程中中性白细胞膜流动性变化 被引量:3

Changes of membrane fluidity of neutrophil during acute myocardialischemia and reperfusion in dog
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摘要 作者观察了犬冠状动脉急性闭塞再灌注过程中中性白细胞膜流动性及血清肌酸磷酸激酶(CPK)的变化.结果表明:冠状动脉左前降支(LAD)阻断后,心大静脉回流血中中性白细胞膜荧光偏振P值升高,阻断前为0.27±0.01,阻断15min为0.29±0.01,中性白细胞膜流动性下降.随缺血时间延长,中性白细胞膜荧光偏振P值明显升高,阻断30min为0.30±0.01,阻断60min为0.32±0.01(与阻断15min比P<0.05).再灌注后,中性白细胞膜荧光偏振P值继续升高.中性白细胞荧光偏振P值与血清CPK浓度呈正相关(r=0.89,P<0.05).结论:心肌缺血再灌注过程中中性白细胞膜流动性降低,并与血清CPK值密切相关. The changes of neutrophil membrane fluidity and serum creatine phosphokinase(CPK )were ob-served during acute coronary artery occlusion and reperfusion in dog.The results were as follows: With theleft anterior descending branch(LAD)of coronary artery occluded ,the P value of fluorescence polarization ofneutrophil in great cardiac vein was increased from preoccluded 0.27±0.01 to 15 min occluded 0.29±0.01. The neutrophil membrane fluidity was lower.The P value of neutrophil fluorescence polarization was signifi-cantly augmented with prolonged LAD occlusion,P=0.30±0.01 when occluded for 30 min,P=0.32±0. 01after occluded 60 min(P<0.05 compared with 15 min occluded).The increase of P value of neutrophil fluo-rescence polarization was continued during reperfusion.The P value of neutrophil fluorescence polarizationwas positively correlated with the activity of serum CPK(r=0.89,P<0.05).Conclusion :The membranefluidity of neutrophil is decreased during acute myocardial ischemia and reperfusion.It is closely correlatedwith the activity of serum CPK.
出处 《第四军医大学学报》 1995年第2期99-101,共3页 Journal of the Fourth Military Medical University
关键词 再灌注损伤 嗜中性白细胞 膜流动性 心肌缺血 myocardium ischemia:reperfusion neutrophils membrane fluidity
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