茅丹黄对氯化汞致兔急性肾功能衰竭的疗效研究

Effect of“ maodanhuang”on acute renal failure induced by HgCl_2 inrabbits

作者以中药茅丹黄治疗ＨｇＣｌ＿２复制的家兔急性肾功能衰竭，３０只兔随机分为中药治疗组和盐水对照组．结果表明：①治疗组肾功能损害减轻．治疗后５ｄ时尿肌酥０．４０±０．１９ｍｍｏｌ／２４ｈ，８ｄ时血尿素氮１１．０９±４．３６ｍｍｏｌ／Ｌ，血清肌酥１１４．９８±３０．１３μｍｏｌ／Ｌ；而对照组的相应指标分别为０．２１±０．１５ｍｍｏｌ／２４ｈ，１４．４０±１１．９２ｍｍｏｌ／Ｌ，１６３．８１±５３．７７μｍｏｌ／Ｌ，各对应Ｐ值均小于０．０５．②低比重尿持续时间：治疗组为４．０９±１．５７ｄ，对照组为６．７３±２．３３ｄ（Ｐ＜０．０５）．③肾脏血流动力学：血流速度时间积分，峰值血流速度，每搏通过肾血流量，肾动脉血流量以及④肾组织学改变均以治疗组恢复快．提示茅丹黄对重金属ＨｇＣｌ＿２所致兔中毒性急性肾功能衰竭有良好保护作用，可试用于临床．

The effects of″maodanhuang″on the HgCl_2-induced acute renal failure was studied in rabbits,which were randomly divided into″ maodanhuang″treatment group (Tr,n=15) and salt water control group (Co,n=15).The renal function and renal hemodynamics were observed. The results showed as follows:onthe 5th day u-Cr was0. 40± 0.19 mmol/24h,on the 8th day BUN was 11. 09 ± 4.36 mmol/L and s-Cr114. 98 ±30.13 μmol/L in Tr group while they were respectively 0. 21 ± 0.15 mmol/24 h,14. 40 ± 11.92mmol/L and 163. 81±53. 77 μmol/L in Co group.Hyposthenuria period was 40. 9± 1. 57 d in Tr group and6.73±2.33 d in Co group.The difference between the two groups were statistically significant (P<0. 05).The renal hemodynamics and histological changes in Tr group were also better than Co group. Our results in-dicate that the“maodanhuang” can considerably protect rabbits kidney from acute renal failure caused by ad-ministering HgCl_2.It suggests that this method should be clinically used.