高渗盐水复苏对失血性休克兔脏器血流量的影响

The effects of hypertonic saline resuscitation from hemorrhagicshock on the vesceral blood flow in rabbits

目的：探讨高渗盐水复苏对失血性休克兔脏器血流量的影响及机理．方法：健康家兔按２０ｍｌ／ｋｇ体重放血致失血性休克，６０ｍｉｎ后，分别回输１０％放血量的抗凝自体全血（自血）、生理盐水及高渗盐水，记录不同时刻颈动脉压，采用放射性微球技术检测动物心、肾、胃及空肠血流量．结果：高渗盐水复苏后，失血性休克家兔平均动脉压迅速提高，脏器血流量增加，显著高于缺血对照组（Ｐ＜０．０５或Ｐ＜０．０１）．结论：高渗盐水复苏失血性休克，可迅速提高动物平均动脉压，改善脏器灌流．

Objective:The study was designed to investigate the mechanism of changes in vesceral blood flowfollowing resuscitation from hemorrhagic shock in rabbits with hypertonic saline. Methods:Thirty rabbitswere divided into five groups at random. Sixty minutes after blood letting in a volume of 20 ml/kg bodyweight, heparinized blood, normal saline and 1282 mmol/L NaCl were separately administered in a volumeapproximating 10% of shed blood volume. The mean arterial pressure(MAP)were recorded during the ex-perimental procedure. The vesceral blood flow measurements were obtained by radioactive microsphere tech-nique. Results:The vesceral blood flow and MAP in rabbits were significantly(P<0. 05 or P<0.01)greater in hypertonic saline group than in the ischemia control group after resuscitation. Conclusion:Hyper-tonic saline may increase vesceral blood flow and MAP quickly following resuscitation from hemorrhagicshock in rabbits.