摘要
作者用离体兔心含血逆行灌注模型，研究了六甲氧苄嗪（ＨＭＺ）对全心缺血后再灌注心肌酶谱和再灌注心律失常（ＲＡ）的影响．结果表明，ＨＭＺ能显著降低再灌注期间磷酸肌酸激酶（ＣＰＫ），乳酸脱氢酶（ＬＤＨ）和谷草转氨酶（ＧＯＴ）的含量，与生理盐水对照组比较（Ｐ＜０．０５和Ｐ＜０．０１），同时发现该药能明显抑制ＲＡ的发生．提示该药对缺血再灌注损伤心肌有较好的保护作用．
With a model of the isolated blood-contained reperfused rabbit heart,the effects of
hexametazidine(HMZ) were studied on the enzymogram of reperfused myocardium and
reperfusive arrhythmia following is-chemia of the whole heart.The results showed that HMZ
significantly reduced the contents of phosphocre- atinase,lactic dehydrogenase and
glutamic-oxaloacetic transaminase during reperfusion. Compared with the saline control(P< 0.
05 &P<0. 01 ),it was found that HMZ could apparently inhibit the occurrence of reperfusive
arrhythmia,suggesting HMZ is a good protection against the ischmia-and reperfusion-induced
damage of myocardium.
出处
《第四军医大学学报》
1995年第4期251-253,共3页
Journal of the Fourth Military Medical University
关键词
心肌缺血
再灌注损伤
预防
六甲氧苄嗪
hexametazidine
creatine kinase
glutamic-oxaloacetic
transaminase
lactic dehydrogenase
ar- rhythmia,reperfused
