槲皮素、芦丁和BHT对低密度脂蛋白氧化修饰的抑制效应

Effects of quercetin,rutin an BHT on the oxidative modification of low density lipoprotein induced by Cu￣+

本研究以与低密度脂蛋白（ＬＤＬ）氧化修饰程度相关的指标：ＬＤＬ的维生素Ｅ含量、游离氨基减少百分率、巴比妥酸反应物质（ＴＢＡＲＳ）和荧光物质的产生量，比较了槲皮素、芦丁与ＢＨＴ的抗低密度脂蛋白脂质过氧化能力。结果显示：槲皮素、芦丁抗氧化能力近似，二者均优于人工合成的酚类物质ＢＨＴ。

The blochemical indexes related to oxidative modlfication of low density lioptrotein(α-Tocopherol,free amino group,thiobarbituric acid reactive substances content,and intensity of emission fluoresence)were used to compare the effects of quercetin,rutin and 3,5-ditert- buty1-4-hydroxytoluene(BHT)on theoxidative modification of LDL.The results indicate that the protective effects of quercetin and rutin againstlipid peroxidation of LDL are similar and better than those of BHT.