芦丁、槲皮素对已受到Fe^（2＋）和Cu^（2＋）氧化修饰的低密度脂蛋白的抑制

Comparable study of the inhibitory effects of rutin and quercetin on Oxidative modification of LDL already induced bv Fe￣(2+) and Cu￣(2+)

以反映低密度脂蛋白（ＬＤＬ）氧化修饰程度的硫代巴比妥酸反应物质（ＴＢＡＲＳ）及荧光物质含量为指标，研究了芦丁、槲皮素对已受到Ｆｅ￣（２＋）和Ｃｕ￣（２＋）氧化修饰ＬＤＬ的抑制作用。结果表明：槲皮素、芦丁对已受到Ｆｅ￣（２＋）氧化修饰ＬＤＬ有明显的抑制作用，芦丁优于槲皮素；而对已受到Ｃｕ￣（２＋）氧化修饰的ＬＤＬ，槲皮素显示了较为显著的抑制作用，芦丁只具有轻微的作用。

In the study ,using the content of thiobabituric acid reactive substance(TBARS)and emission fluores-cence as indexes,the inhibitory effects of rutin and quercetin on oxidative modification of LDL al-ready induced by Fe￣(2+)and Cu￣(2+) were compared.The results showed that,with LDL already induced byFe￣(2+),both rutin and quercetin could inhibit the oxidative modification and the role of rutin is better thanthat of quercetin;with LDL already induced by Cu￣(2+),quercetin had significantly higher efficiency andrutin only had a slight function.