摘要
应用心脏电刺激技术和单相动作电位记录技术,从心室复极化时程、时相及复极化离散性和心室肌电稳定性的角度,研究口服奎尼丁和胺碘酮4周后对心室电生理效应的影响及其差异。结果表明,奎尼丁和胺碘酮有相似的心室电生理效应,包括延长心室有效不应期和心室复极化时程。但是奎尼丁对延长复极化后期的作用尤为突出,且使复极化离散性增加,对心室纤颤阈值无显著影响;而胺碘酮均一同步地延长复极化时程,不影响复极化离散性,且使心室纤颤阈值上升,提高心室肌电稳定性。
Abstract Department of Internal Medicine,3rd Hospital Affiliated to Sun Yat-sen University of
Medical c,Sciences Department of Cardiology,Sun Yat-sen Memorial Hospital,Sun Yat-sen
University of Medical Sciences The ventricular electrophysiologic effects of chronically orally
administered quinidine and amiodaronewere studied in canine models with the techniques of
electric stimulation and monophasic action potential(MAP)recording, Twenty-two adult mongrel
dogs were randomizedly allocated into 3 groups :Group 1(n=8)served as normal controls.
Group 2(n= 7)were given quinidine orally 400mg a day for 4 weeks. Group 3(n=7)were given
amiodarone orally 400mg a day for 4 weeks. The results showed that in
anes-thetized,open-chest dogs :(1)The general ventricular electrophysiologic effects of
quinidine were similarto those of amiodarone; both increased ventricular effective refractory
period(VERP. Quinidine :192±30to 135±12, P<0.01 ; Amiodarone: 205±26 to 135±12, P<0.
01)and ventricular repolarization(QT in-terval.Quinidine:332±35 to 210±
19,P<0.01;Amiodarone:341±17 to 210±19, P<0. 01);(2)Quini-dine lengthened ventricular
repolarization unsynchronously and inhomogeneously and the lengthening is ob-served
mainly in phase 3 of action potential;whereas, amiodarone lengthened ventricular
repolarizationsynchronously and homogeneously;(3)Amiodaronie increased ventricular electric
stability characterized byan elevation of ventricular fibrillation threshold (VFT,38±6 to 25±6,
P<0.01),while quinidine had nosignificant effect on VFT(26±8 to 25±6,P>0.05).This study
might explain why clinically quinidine andamiodarone lengthened QT interval to a simillar
extent, but amiodarone had a higher cardiac safety thanquinidine.
出处
《第一军医大学学报》
CSCD
1995年第2期121-123,共3页
Journal of First Military Medical University