梭曼对小鼠淋巴细胞增殖能力的影响

Effects of Soman on Lymphocyte Proliferation in Mice

研究了梭曼对小鼠淋巴细胞增殖能力的影响。大剂量(154μg/kg,SC)梭曼中毒后第1天起,B细胞对LPS的反应明显下降,3～5天抑制最甚,第10天方恢复至对照水平,ConA诱导的T细胞反应呈先增强后抑制的双相变化。T-、B-细胞丝裂原反应的下降及早期T-细胞反应的增强都与梭曼剂量密切相关而与全血胆碱酯酶活力的变化似无直接关系。

Effects of soman on lymphocyte proliferation are investigated in mice. 1 d after soman(154 μg/kg,sc) poisoning B-lymphocyte reaction to lipopolysaccharide(LPS) is inhibited significantly and is persistent.T-cell proliferation response stimulated by concanavalin(Con A)has a 2-phase changeson the 1st day an increase followed by a dramatical reduction. Both the decreases of T-and B-lymphocyte mitogenic response and the primary increase of T-cell response show a close correlation with the doses of soman in this experiment. It has no relation to the change of the whole blood cholinesterase activity.