犬烟雾吸入性损伤早期肝脏的病理变化

An Experimental Study on Pathological Changes of Liver in Dogs with Smoke Inhalation Injury

本文系研究犬烟雾吸入性损伤早期肝脏的病理组织学和超微结构变化。实验结果表明,其变化主要表现为肝细胞变性、坏死和枯否氏细胞增生、吞噬增强与继之退变。这些变化于伤后2h即出现,且较明显,6h加重,24h渐减轻。此动态性变化与动物烟雾吸入后血内COHb的变化规律基本相符合。作者认为,一氧化碳中毒在烟雾吸入性损伤早期肝脏病变的发生中显然起着重要的作用。

Light and electron microscopic changes of the liver of dogs after smoke inhalation injury are described in detail to demonstrate the effects of smoke inhalation on liver. The temperature of the inhaled smoke is about 36-37℃. The results of this study are the same as the steam inhalation injury. The main pathological findings are degeneration and necrosis of hepatic cells and proliferation of Kupffer cells showing active phagocytosis. These lesions appear on the 2nd day and progressively exaggerate on the 6th day after smoke inhalation injury and then reduce gradually. These dynamic changes are parallel to that of COHb. Thus the authors consider that the carbon monoxide poisoning and anoxia may be the main cause of the hepatic lesions.