扑尔敏的示波极谱测定

Determination of Chlorpheniramine Maleate by Oscillographic Polarography

在０．１ｍｏｌ／Ｌ的Ｈａｃ－ＮａＡｃ缓冲溶液中，扑尔敏于—１．３６Ｖ（ｖｓ．ＳＣＥ）处产生一灵敏的极谱还原波，导数波高与扑尔敏在２．０×１０^（－６）～８．０×１０^（－５）ｍｏｌ／Ｌ浓度范围内成线性关系，检测下限达６．０×１０^（－７）／ｍｏｌ／Ｌ。对极谱波的性质进行了探讨，并用该法测定了速效伤风胶囊中扑尔敏的含量。

In a 0.1 mol/L HAc+NaAc buffer solution of pH 4.7,chlorpheniramine maleate gives a sensitive adsorptive peak on the oscillographic polarograph at 1.36V(vs.SCE).A linear relationship between peak current and concentration of chlorpheniramine maleate was obtained in the range of 2.0×10(-6)to 8.0×10(-5)mol/L.The detection limit is 6.0×10(-7) mol/L.The proposed method has been employed for the determination of chlorpheniramine maleate in the quick-acting antihistamine capsules──Shuxiaoshangfeng.