大豆黄酮对大鼠肌肉生长和几种内源激素水平的影响

EFFECTS OF DAIDZEIN ON MUSCLE GROWTH AND SOME ENDOGENOUS HORMONE LEVELS IN RATS

给雄性、雌性和雄性去势大鼠皮下注射大豆黄酮［３ｍｇ／（１００ｇ体重·天）］１６天。结果：雄性大鼠日增重提高１４．７％（Ｐ＜０．０５），耗料与增重比降低１２．０％，后腿肌重和后腿肌总ＲＮＡ含量显著增加，而总ＤＮＡ含量无显著变化；血清脲氮水平显著下降，血清睾酮、雌二醇、生长激素和β－内啡肽含量显著提高。雄性去势大鼠日增重、后腿肌重无显著变化，血清睾酮、生长激素和β－内啡肽水平虽显著高于对照组，但睾酮水平仅为同等条件下完整大鼠的８％左右。雌性大鼠日增重降低１９．０％（Ｐ＜０．０１），耗料与增重比提高１７．８％，血清睾酮、雌二醇和生长激素水平显著降低。试验结果表明：大豆黄酮对大鼠肌肉生长和几种内源激素水平的影响呈现性别差异，对雄性大鼠肌肉生长的促进作用依赖于睾丸的内分泌机能。

Daidzein[3 mg/(100g body weight·day)] was injected subcutaneously for 16 days in male,female and castrated male rats.To the male rats,average daily body weight gain increased by 14.7%(P<0.05),feed consumption to body weight gain ratio decreased by 12.0%,hind leg muscle weight,total RNA content of hind leg muscle increased signiflcantly,and no apparent difference was found in total DNA content.Blood urea nitrogen decreased significantly,whereas serum testosterone,estradiol,β-endorphin and growth hormone increased obviously.To the castrated male rats,no considerable differences were found in average daily body weight gain and hind leg muscle weight,although concentrations of serum growth hormone,β-endophin and testosterone increased significantly.However,the testosterone level of castrated male rats was about 8.0% of that of intact male rats.To the female rats,the average daily body weight gain decreased by 19.0%(P<0.01).The levels of serum testosterone,estradiol and growth hormone significantly decreased.The results showed that the effects of daidzein on muscle growth and some endogenous hormone levels in rats exhibited sex difference.The promoting effect of daidzein on male rats seems depending on the function of testis.