Cd^(2+)对离体的鲤鱼脑垂体分泌促性腺激素的影响

EFFECT OF Cd^(2+) ON GONADOTROPIN SECRETION OFPITUITARY FROMCOMMON CARP (Cyprinus carpio L.) IN VITRO

采用离体的鲤鱼脑垂体灌流孵育系统,研究重金属镉离子(Cd^(2+))对脑垂体分泌促性腺激素(GtH)的毒害影响。发现Cd^(2+)既能直接刺激GtH分泌,又抑制鲑鱼促性腺激素类似物释放激素(sGnRH-A)刺激脑垂体分泌GtH作用。实验结果提示,Cd^(2+)对鲤鱼脑垂体GtH分泌细胞的毒害机制之一可能是它干扰了Ca^(2+)的正常生理作用。

Effects of Cd2+on gonadotropin secretion of pituitary from common carp were studied by using the in vitro perfusion system. It was found that Cd2+ can stimulated gonadotropinsecretion directly, inhibited sGnRH-A stimulating gonadotropin secretion significantly. The results suggest that one of the toxic mechanisms of Cd2+ on pituitary gonadotrop might be Cd2+ - disturbed Ca2+ action.