缺氧或二氧化碳负荷下通气功能及呼吸型式的比较

Comparison of Ventilatory Function and Respiratory Pattern during Hypoxic or Hypercapnic Loading

作者用重复呼吸法造成等CO_2张力性缺氧或高氧张力性CO_2负荷,比较同一批被试者的通气功能和呼吸型式。实际数据进行联机实时处理。结果:①在三种等CO_2水平下,V_I、(?)_t、及P_(0.1)均分别与P_(ETO_2)呈双曲线函数关系;高CO_2负荷下,V_I、(?)_I及P_(0.1)均分别与P_(ETCO_2)呈线性函数关系;不同化学负荷下,P_(0.1)/V_I、P_(0.1)/(?)_t间均呈高度相关,而其相应直线回归系数间亦无显著性差别。②个体化学负荷敏感性比较表明,对CO_2敏感者通常对缺氧亦较敏感,但不同个体间存在较大差异。③不同化学负荷下,均随着V_T增加,T_E渐趋缩短,T_I基本不变;进行P_(0.1)测量时,可致T_I缩短,T_E、V_I、(?)_t、f和V_T均无显著性意义的变化。结论:口腔关闭压是较为好用的呼吸驱动指标。

The present paper reports comparison of ventilatory function and respiratory pattern response to progressive isocapnic hypoxia and hyperoxic hypercapnia, using a rebreathing method. Experimental paraments were measured by an on-line MDR-Z80 computer. The results showed: (1) During the hypoxic loading of three TETCO2 levels, VI,VI and P0.1 were the hyperbol ic functions of PETCO. respectively. At the hypercapnic loading, VI ,VI and P0.1 had the linear functions with PETCO respectively.At the hypoxic and hypercapnic loading, there were significantly linear relationships between VI and P0.1 , as well as VI and P0.1. Their regressive coefficients were not significantly different (P>0.05). (2) Comparison of individual chemical sensitivity showed that the more sensitive individual is to hypercapnia, the more sensitive to hypoxia. But there were significant differences among individuals. (3) At hypoxic and hypercapnic loading, respiratory pattern showed that TE is decreased and TI is kept constant with increased VI. Because of the airway occlusion of PO.I measurement, TI was shortened (t test for pair values, P<0.01) and TE was not changed significantly (P>0.05). There were no affects on VI,VI, f and VI (P> 0.05). According to our results, we confided that occlusion pressure as an index of inspiratory center drive is feasible.