武汉地区汉族人群补体第二成分(C2)的遗传多态现象

Genetic Polymorphism of the Second Component of Human Complement (C2) in the Han Nationality in Wuhan District of China

使用聚丙烯酰胺凝胶等电聚焦溶血覆盖技术,调查了武汉地区231例汉族人的C2多态现象。C2表型为C2C的216人,C2BC9人,C2AC5人,C2A1人。基因频率为:C2~*A 0.0151,C2~*B 0.0195, C2~*C 0.9654。

A total number of 231 unrelated Chinese (Han Nationality) were investigated for C2 polymorphism by hemolytic overlay technique after polyacrylamide gel isoelectric focusing on plasmas.The following phenctype distributions were observed:C2C,216; C2BC,9; C2AC,5; and C2A,1.The gene frequencies calculated from these phenotypes were as follows:C2*A,0.015; C2*B,0.019; C2*C,0.965.The C2 phenotypic frequency distributions were in agreement with those expected from Hardy-Weinberg equilibrium.